Why don't they add grapefruit extract to drugs so people won't need as much of
9 years ago by onhu · 1761 Likes · 12 comments · Popular
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deleted
· 9 years ago
· FIRST
My blood pressure medicine says that.
4
whospikedthepunch
· 9 years ago
Yep two of mine do, one says that grapefruit could cause fainting, something I'd like to avoid while running heavy equipment!
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deleted
· 9 years ago
If you add grapefruit extract to the drug the person could die. It has averse (bad) effects.
10
jimcrichton
· 9 years ago
Perhaps when a drug tests as too weak to be effective, instead of rejecting it in favor of others, we should try adding grapefruit extract to the drug formulation.
deleted
· 9 years ago
If I have grapefruit with my meds I'll go into a coma and probably die
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guest
· 9 years ago
Some thing about the liver wasn't it? It prevents it from processing the drug but
2
megara
· 9 years ago
Most blood pressure medications do, however you would have to eat grapeftuit in such large amounts most pharmacies dont tend to worry about putting the auxillary label on each time.
reallychelseawow
· 9 years ago
It also makes birth control less effective, ladies!
toclafane
· 9 years ago
I was researching the drastically reduced half maximal inhibitory concentration of nanoencapsulated epigallocatechin-3-gallate versus naturally occurring EGCG with regards to cancer chemoprevention effects. I wonder if grapefruit furanocoumarins would increase the bioavailability of EGCG and make grapefruit-fortified green tea an effective cancer prevention regimen.
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jimcrichton
· 9 years ago
Neat! How were you nanoencapsulating it the EGCG (if you're at liberty to say)? And how did you keep the catecholic moieties from complexing to anything they got near? (I just realized these might have the same answer.)
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toclafane
· 9 years ago
I don't really think I could say much; there are patents involved. I can say that it uses polylactic acid-polyethylene glycol copolymer (which is a very common nanoparticle copolymer). As you implied, the EGCG does not transport well through the digestive system or blood, so the bioavailability is very low. However, the nanoencapsulated form does transport well, and the nano-EGCG increases Bax, decreases Bcl-2, induces PARP cleavage, and inhibits FGF-associated angiogenesis at about 10% the IC50 of the native form of EGCG under various test concentrations (with p <.01).
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icyquiet
· 9 years ago
So if someone wanted to OD, they could take some grapefruit along with their medication? o.o
