Perhaps when a drug tests as too weak to be effective, instead of rejecting it in favor of others, we should try adding grapefruit extract to the drug formulation.
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· 9 years ago
If I have grapefruit with my meds I'll go into a coma and probably die
Most blood pressure medications do, however you would have to eat grapeftuit in such large amounts most pharmacies dont tend to worry about putting the auxillary label on each time.
I was researching the drastically reduced half maximal inhibitory concentration of nanoencapsulated epigallocatechin-3-gallate versus naturally occurring EGCG with regards to cancer chemoprevention effects. I wonder if grapefruit furanocoumarins would increase the bioavailability of EGCG and make grapefruit-fortified green tea an effective cancer prevention regimen.
Neat! How were you nanoencapsulating it the EGCG (if you're at liberty to say)? And how did you keep the catecholic moieties from complexing to anything they got near? (I just realized these might have the same answer.)
I don't really think I could say much; there are patents involved. I can say that it uses polylactic acid-polyethylene glycol copolymer (which is a very common nanoparticle copolymer). As you implied, the EGCG does not transport well through the digestive system or blood, so the bioavailability is very low. However, the nanoencapsulated form does transport well, and the nano-EGCG increases Bax, decreases Bcl-2, induces PARP cleavage, and inhibits FGF-associated angiogenesis at about 10% the IC50 of the native form of EGCG under various test concentrations (with p <.01).
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