Yes, we are very tiny and fragile and most of everything in the universe can kill us in a nanosecond. Still, we're very complex things, more complex than pretty much anything of planetary to cosmological scales. Most of the universe is an unconscious blob of gases and dark matter, life is rare, and for all we know, we might be the only creatures in the Universe who are able to actually understand this universe. We're tiny, not insignificant.
No giant "your mom" at the end
The universe doesn't give a s**t about you
OK I'm very sorry