I'm calling it, with his dying breath Elon Musk will give the order to explore and potentially colonise the Andromeda galaxy. Already got the required spacesuit design down pat.
Historically, astronauts have always worn nappies/diapers. If you have to do repair work outside the space craft, or if you are going exploring, you can't just keep going back inside to go to the bathroom - it'd be a waste of time and oxygen.
Given that time span from now, we might be leaving the solar system for the first time.