You can only understand this with a big brain

E?

Step by step solution
Step 1: Write down the binary number:
1000101
Step 2: Multiply each digit of the binary number by the corresponding power of two:
1x26 + 0x25 + 0x24 + 0x23 + 1x22 + 0x21 + 1x20
Step 3: Solve the powers:
1x64 + 0x32 + 0x16 + 0x8 + 1x4 + 0x2 + 1x1 = 64 + 0 + 0 + 0 + 4 + 0 + 1
Step 4: Add up the numbers written above:
64 + 0 + 0 + 0 + 4 + 0 + 1 = 69.
So, 69 is the decimal equivalent of the binary number 1000101.

And then there's me, who doesn't know binary but knows pretty darn well which number is indicated by the nice meme